Synthroid Uses, Dosage & Side Effects

Use this section to review the cases of Steve, Jennifer, and Diana to see how to effectively manage their hypothyroidism with SYNTHROID (levothyroxine sodium). Levothyroxine toxicity is rare, but it can sometimes occur accidentally, especially in children. If someone takes too much levothyroxine, symptoms might not occur for several days. Symptoms of levothyroxine overdose include irregular heartbeat, headache, anxiety, agitation, shaking, fatigue, confusion, and disorientation. Certain foods and medications can interfere with the absorption of levothyroxine.

¿Cuáles son los posibles efectos secundarios de levothyroxine?

Monitor for cardiac arrhythmias during surgical procedures in patients with coronary artery disease receiving suppressive SYNTHROID therapy. Monitor patients receiving concomitant SYNTHROID and sympathomimetic agents for signs and symptoms of coronary insufficiency. Consider changes in TBG concentration when interpreting T4 and T3 values.

DRUG INTERACTIONS

The recommended daily dosage of SYNTHROID in pregnant patients is described in Table 3. Certain side effects can occur with Synthroid, and these are often the result of your bodygetting too much medicine, also known as overtreatment. So it’s important to talk with yourdoctor about any symptoms you’re experiencing. Synthroid is a thyroid medicine that replaces a hormone normally produced by your thyroid gland to regulate the body’s energy and metabolism. SYNTHROID is not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients, as there are no clinical benefits and overtreatment with SYNTHROID may induce hyperthyroidism.

Some people might use their levothyroxine prescriptions for this reason, but it’s important to know that the use of levothyroxine for weight loss can result in dangerous and potentially life-threatening side effects. Thyroid hormones can also be present illicitly in some over-the-counter weight loss products. These dietary supplements can contain varying amounts of thyroid hormones, which can be dangerous and cause adverse effects. Because of this, people should not take over-the-counter weight loss supplements.

This medicine can cause some serious health issues

Because some preparations of the drug may contain iodine or lactose, patients should tell their doctors about such allergies or reactions to these components. Circulating thyroid hormones are greater than 99% bound to synthroid alli plasma proteins, including thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (TBA), whose capacities and affinities vary for each hormone. The higher affinity of both TBG and TBPA for T4 partially explains the higher serum levels, slower metabolic clearance, and longer half-life of T4 compared to T3.

Synthroid Side Effects That Might Mean Your Dosage Is Way Off

Common brand names of levothyroxine in the US include Synthroid, Levoxyl, Unithroid, and Tirosint. A study evaluated the effect of long-term thyroid hormone therapy on bone mineral density in 196 women (mean age, 74.4 years) compared to a control group comprised of 795 women (mean age, 72.1 years). The mean daily thyroxine dose was 1.99 mcg/kg (range, 0.3 to 6.6 mcg/kg) with a mean duration of therapy of 20.4 years (range, less than 1 to 68 years).

Clinical Pharmacology for Synthroid

Eltroxin is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Unithroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … NP Thyroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, thyroid cancer … Euthyrox (levothyroxine) is used to treat hypothyroidism and to treat or prevent goiter. Tirosint is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … This is not a complete list of side effects and others may occur.

• SYNTHROID is contraindicated in patients with uncorrected adrenal insufficiency see WARNINGS AND PRECAUTIONS.
• Symptoms of levothyroxine overdose include irregular heartbeat, headache, anxiety, agitation, shaking, fatigue, confusion, and disorientation.
• Consider the potential for food or drug interactions and adjust the administration or dosage of SYNTHROID as needed see DOSAGE AND ADMINISTRATION, DRUG INTERACTIONS and CLINICAL PHARMACOLOGY.
• «Because it mimics the hormones your body makes naturally, side effects of Synthroid are more often from having the wrong dosage than from the drug itself,» she says.
• Tirosint is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma …

Pregnant and lactating females need to discuss the dose and use of this medication with their caregivers. This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

In adult patients with primary hypothyroidism, monitor serum TSH levels after an interval of 6 to 8 weeks after any change in dosage. In patients on a stable and appropriate replacement dosage, evaluate clinical and biochemical response every 6 to 12 months and whenever there is a change in the patient’s clinical status. The recommended starting daily dosage of SYNTHROID in pediatric patients with primary, secondary, or tertiary hypothyroidism is based on body weight and changes with age as described in Table 2. Titrate the dosage (every 2 weeks) as needed based on serum TSH or free- T4 until the patient is euthyroid see Important Considerations For Dosing. Myxedema coma is a life-threatening emergency characterized by poor circulation and hypometabolism and may result in unpredictable absorption of levothyroxine sodium from the gastrointestinal tract. Use of oral thyroid hormone drug products is not recommended to treat myxedema coma.

Toxic effects may include increased risk of cardiac arrhythmias and central nervous system stimulation. Administration of sertraline in patients stabilized on SYNTHROID may result in increased SYNTHROID requirements. TSH may not normalize in some patients due to in utero hypothyroidism causing a resetting of pituitary-thyroid feedback. Assess compliance, dose of medication administered, and method of administration prior to increasing the dose of SYNTHROID see WARNINGS AND PRECAUTIONS and Use In Specific Populations.